Physico-chemical characterization of a biological drug

Terrmin

HT21

Beskrivning

Lanreotide is an amphiphilic peptide drug used in the treatment of acromegaly and symptoms caused by neuroendocrine tumors. Lanreotide is expected to interact strongly with various excipients, but at present it is largely unknown what kind of structures that may form. It is also not fully understood under what circumstances lanreotide is soluble or not in aqueous solutions.

The aim of this project is to study physico-chemical properties of lanreotide, such as solubility and self-assembly, at different conditions, for instance ionic strength, pH or presence of a co-solvent. The size, shape and structure of aggregates or nanoparticles will be characterized with advanced experimental techniques, mainly small-angle x-ray scattering (SAXS) as well as static and dynamic light scattering (SLS and DLS). Complementary techniques such as electron microscopy and time-resolved fluorescence quenching may as well be considered.

Huvudområde

Farmaceutisk kemi

Ämne

Fysikalisk kemi

Typ

Laborativ studie

Företag

Institutionen för läkemedelskemi

Ort/Plats

Uppsala Universitet

Handledarens namn

Magnus Bergström

Handledarens e-post

magnus.bergstrom@ilk.uu.se

Institution

Program

Kurs

Omfattning/hp

30hp

Hur många studenter kan antagas för detta projekt?

1

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