ProjektportalPeptide drug delivery using hydrophobically modified hyaluronic acid – studies of interaction and phase behaviour in solution
Terrmin
HT21
Beskrivning
Bakgrund: HA nanogel is composed of cholesterol substituted hyaluronic acid (HA), which forms a nano-sized hydrogel particle in water by self-assembly. HA nanogel can host various types of drug molecules via hydrophobic and ionic interaction. This can be used to reach sustained release and to solubilize/de-aggregate drugs. HA nanogel can load versatile drug molecules such as proteins, peptides, and small molecules.
Task: Investigate the interaction between hydrophobically modified hyaluronic acid and model peptides to understand how aggregation and phase behaviour can be used to gain systems for sustained subcutaneous (injectable) drug delivery.
Methodology: Use of light scattering and fluorescence techniques to characterize aggregation and particle gel formation and Small-angle X-ray Scattering (SAXS) to characterize phase structure. Rheological behaviour will be investigated to understand injectability and dissolution studies to understand in-vitro release performance.
Supervisor: Prof. Per Hansson, institutionen för läkemedelskemi, UU. The work will be part of the SweDeliver center including collaborations with industrial partners such as for example AstraZeneca
Huvudområde
Läkemedelsutveckling
Ämne
Fysikalisk kemi
Typ
Laborativ studie
Företag
Uppsala University
Ort/Plats
Uppsala
Handledarens namn
Per Hansson, Marcus Wanselius
Handledarens e-post
per.hansson@ilk.uu.se
Institution
Program
Kurs
Omfattning/hp
30hp
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1