ProjektportalUnderstanding the compression-decompression cycle during tableting
Terrmin
HT21
Beskrivning
Both compressibility and compactibility of powders are nowadays well understood on a phenomenological level. However, an understanding of the relevance of processes that occur at the particle level is lacking and few, if any, truly mechanistic models of powder compression and compaction exist in the literature. It is here important to consider both the loading and unloading phases of particle/tablet formation to gain a complete understanding of the processes. The aim of the project is to provide an understanding at the particle scale of the processes that control the structure and properties of granules formed by application and subsequent removal of pressure. The goal is to first develop protocols for analytical powder compression focusing on the unloading stage and secondly to develop contact models and modelling procedures that enable the full loading–unloading cycle to be simulated at the particle scale. It is expected that the project will provide new insights into pressure shaping of granules with special emphasis on refined methods for compression analysis and new methodology for simulation of powder compression at high relative densities
Huvudområde
Farmaceutisk vetenskap
Ämne
Galenisk farmaci
Typ
Laborativ studie
Företag
Uppsala University
Ort/Plats
Uppsala
Handledarens namn
Marilena Marinaki and Ann-Sofie Persson
Handledarens e-post
marilena.marinaki@farmbio.uu.se
Institution
Program
Kurs
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1