Agglomerates of different types are frequently used in solid formulation, including tablets and dry powder inhalers. Lately, the interest in using dry technologies for the formation of agglomerates has increased substantially, for example to be used in continuous manufacturing. The manufacturing properties of agglomerates are related to their microstructure and to their composition. The aim of the project is to study the relationship between microstructure and the mechanical and functional properties of agglomerates formed by dry granulation and investigate the effect of composition on such microstructure-property relationships with a special focus on agglomerate plasticity. The aim is further to develop a procedure for the assessment of mechanical properties of agglomerates. The long term outcome of the project is a formulation technology platform for rational engineering of the manufacturing properties of dry granulated particles.
Galenisk farmaci med inriktning mot farmaceutisk teknologi
Maryam Tofiq and Ann-Sofie Persson