Determination of particle elasticity of common pharmaceutical excipients using the unloading curve from compression experiments

Terrmin

HT23

Beskrivning

Background
During compression and compaction of powders, a series of stages occur in sequence and occasionally in parallel. These stages include particle rearrangement, particle plastic deformation or particle fracture and particle elastic deformation. The quality of the tablet depends on all these stages. Analytical powder compression is typically used to analyse particle rearrangement and plastic particle deformation or fragmentation. During analytical powder compression the loading part of the compression curve is considered and the unloading part is neglected. However, the unloading part of the compression curve can potentially be used to characterise elastic properties of powders. The shape of the unloading curve can differ and the region important for the elastic properties is unclear and deserves to be investigated further. In addition, the discriminative ability of analysing particle elasticity from the unloading curve in relation to standard methods such as three-point beam bending and indentation is unknown and highly interesting.

Aim
The overall aim is to thoroughly investigate the unloading curves from compression experiments to identify the critical region of the curve that is related to the elastic properties of the powder. Furthermore, the aim is to relate elastic properties determined from the unloading curve to elastic properties from standard methods to investigate the precision of analysing the compression data.

Expected outcome
It is expected that the proposed project will result in a deeper knowledge on the potential of using the unloading curve for assessing elastic powder properties. Ultimately this can be used to complement an existing protocol for determination of mechanical properties using a single compression experiment.

Huvudområde

Farmaceutisk vetenskap

Ämne

Galenisk farmaci

Typ

Laborativ studie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Ann-Sofie Persson

Handledarens e-post

ann-sofie.persson@farmbio.uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i galenisk farmaci med inriktning mot farmaceutisk teknologi 30 hp - 3FB033

Omfattning/hp

30hp

Hur många studenter kan antagas för detta projekt?

1

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