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Pharmacokinetic evaluation of drugs related to chemotherapy-induced peripheral neuropathy

Terrmin

HT23

Beskrivning

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting adverse effect with a high prevalence for microtubule-targeting agents (MTA). It affects peripheral nerve fibers including autonomic, sensory and motor fibers, and can severely diminish the cancer patient’s quality of life. However, no treatment or prevention is clinically approved to date. Also, pharmacokinetic (PK) data on tissue distribution and exposure is generally lacking, especially in the peripheral nervous system (PNS).
The upcoming project will focus on quantitatively investigating transported of selected MTAs across the different endothelial barriers and the parenchymal cellular barriers in CNS/PNS tissues. In this project, neuropharmacokinetic, equilibrium dialysis, and tissue uptake studies will be performed. LC-MS/MS will be used to determine drug concentrations in the biological samples. Pharmacokinetic parameters will be calculated to further understand the brain distribution of the tested drugs.
Contact: Irena Loryan, irena.loryan@farmaci.uu.se and Milda Girdenyté milda.girdenyte@farmaci.uu.se.

Huvudområde

Farmaceutisk vetenskap

Ämne

Farmakokinetik

Typ

Laborativ studie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Irena Loryan

Handledarens e-post

irena.loryan@farmaci.uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsutveckling

Kurs

Degree project in Drug Discovery and Development 45 c - 3FK044

Omfattning/hp

45hp