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Predict Lung Delivery of Drugs with Physiologically-Based Pharmacokinetic Modelling: Where Are We Now?

Terrmin

HT23

Beskrivning

Pulmonary drug delivery is an attactive delivery method for the treatment of respiratory diseases. Though inhalation is a widely adopted administration method, pharmacokinetic (PK) behaviours within the lung tissue have not been fully understood. For one side, measuring local lung drug concentrations directly requires challeging sampling techniques. For the other side, since the lung is not a homogenous organ, drug disposition in each part of lungs may vary hugely.

Physiologically-based pharmacokinetic (PBPK) modeling, with more detailed description of tissue distribution employed, can bring together lung anatomy, particle deposition, drug dissolution, and transport across membranes together. To describe lung distribution, a model may include plasma, endothelial, interstitial, epithelial, and airway spaces, so that drug distribution into each places can ideally be captured and predicted. By integrating nonclinical information, including drug properties and experimental parameters, with clinical observations, PBPK modeling can offer robust predicted PK profiles and provide efficient drug evaluation.

So far, several publications enabled PBPK modelling of lung PK for mices and humans. However, apporaches of these publication vary. Some publications may describe more about airways of lungs, whereas some put more efforts on desrbing blood perfusion or transporter expressions. This project aims to reviewe and summerise published PBPK models for lung delivery, in order to understand essential components of lung PBPK modelling predict local concentration of drugs, as well as critically compare the current models in model performances and inclusiveness of essential kinetic processes.

The work will be carried out in Uppsala, however in a research group, that offers an international environment. The working language, including supervision, will be English.

Does this project sounds like something for you? Apply here or contact the supervisor (see below) or Maria Kjellsson (maria.kjellsson@farmaci.uu.se) if you have additional questions. We look forward to your application!

Huvudområde

Farmaceutisk vetenskap

Ämne

Farmakokinetik

Typ

Litteraturstudie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Haini Wen

Handledarens e-post

haini.wen@farmaci.uu.se

Institution

Institutionen för farmaci

Program

Receptarieprogrammet

Kurs

Fördjupningsprojekt i farmakokinetik 15 hp - 3FB061

Omfattning/hp

15hp