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Composition-structure-function relationships for inhalation powders prepared by spray drying

Terrmin

HT23

Beskrivning

Background

Drug delivery to the lungs is commonly used to treat diseases such as asthma and chronic obstructive pulmonary disease. The lungs have a large surface area available for absorption, a high vascularization, and a thin blood-alveolar barrier, which makes the pulmonary delivery route an interesting alternative for a range of drugs, including new modalities (e.g. insulin, vaccines and growth hormones). Drug delivery to the lung is generally accomplished with an inhaler. Out of these, the dry powder inhalers (DPIs) have become increasingly popular during the last decades, thanks to advantages related to stability of the drug substance, versatility and ease of operation. Traditionally, inhalation powders have with some exceptions been designed in the form of carrier-based formulations (adhesive mixtures). However, there is today an increased interest in using spray drying to prepare inhalation powders for different types of drugs and to use these as so-called carrier-free formulations. With adequate processing parameters, it is possible to retain the biological activity of heat-sensitive drugs such as peptides, oligonucleotides and other biologics. Moreover, higher doses of active pharmaceutical ingredients (APIs) can potentially be delivered to the lung if carrier-free formulations are used.

Your task

The overall aim of the project is to provide an improved understanding of how the composition and manufacturing conditions affect the performance of inhalation powders. Your task will therefore be, first, to prepare powders with different compositions and possibly different processing parameters and, second, to characterize the obtained powders, e.g. in terms of aerosolization performance.

Although the work will be carried out in Uppsala, the research environment is international and the working language will therefore be English. Supervision is in English or Swedish depending on the student's preference.

Huvudområde

Farmaceutisk vetenskap

Ämne

Galenisk farmaci

Typ

Laborativ studie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Mayura Talwelkar Shimpi and Göran Frenning

Handledarens e-post

goran.frenning@farmbio.uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Masterprogram i läkemedelsutveckling

Kurs

Degree project in Drug Discovery and Development 45 c - 3FK044

Omfattning/hp

45hp