Projektportal

Startsida Om denna webbplats

Logga in

Physiologically based pharmacokinetic modelling of veterinary species

Terrmin

HT23

Beskrivning

Aim
To build physiologically based pharmacokinetic model(s) for veterinary species and evaluate the model on real world data.
Background
Physiologically based pharmacokinetic (PBPK) models are mechanistic models describing the physiology of an animal. These mechanistic models are compartment-based, and each compartment is described with physiologically relevant parameters. Compartments that are added to the model are a) important for the pharmacokinetics of the drug (i.e. metabolizing or eliminating organs), b) interesting organs or tissues for the purpose of the research (like subcutaneous tissue for drugs administered via that route), and c) rest compartments to describe the remainder of the body that was not added to the model yet. Physiologically based blood flows from and to these organs determine the mass transfer of the drug to and from the compartments.
In the pharmaceutical development, PBPK models are used to predict pharmacokinetics in different ethnic populations, populations of various age or disease states. PBPK models are even used to evaluate different dosing schedules, doses and dosage forms. In toxicology, PBPK models are for example used to evaluate the long-term effect of environmental pollutants, and as risk assessment tools. Even in the veterinary world, these type of models have been used as risk assessment tools, especially to evaluate the risk of secondary ingestion of drugs through ingestion of animal products (like milk and meat).
Possible methods to be used
Literature review and collection of physiological data necessary for the parametrization of the model(s). Build PBPK model(s) in R language or with PK-Sim & MoBi (Open Systems Pharmacology Suite). Knowledge of R or other programming languages and pharmacokinetics is essential to this project.
Student interests
Veterinary medicines, translational science, pharmacokinetics, biopharmaceutics, working with R script, mathematical modelling.

Huvudområde

Farmaceutisk vetenskap

Ämne

Biofarmaci

Typ

Beräkningsstudie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Ilse Dubbelboer

Handledarens e-post

ilse.dubbelboer@farmbio.uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i biofarmaci 30 hp - 3FG008

Omfattning/hp

30hp