Lactational excretion and secondary exposure of xenobiotics

Terrmin

HT23

Beskrivning

Background
Breastfeeding is strongly recommended by WHO, but between 50 – 80% of breastfeeding women use some medication during the first months postpartum. Simultaneously, the majority of medicines have no or weak lactation-specific information. This causes a portion of mothers to stop breastfeeding. And when not, the drug consumption during breastfeeding poses a potential risk for the baby. Meanwhile, there are strict regulations for the use of veterinary medicines in food-producing animals. The regulations stipulate when the milk from treated animals can be added to milk production again.
All mammals produce milk to provide nutrition, energy and immune protection to their young immediately after birth, and the physiology of milk production is similar in all mammals. Therefore utilization of animal data to predict lactational excretion in humans is obvious, but happens seldomly. The wealth of animal data available due to food-consumption regulation can be used in risk assessments for humans. This type of comparative and translational work is a step towards assessing the risk of human drug consumption during lactation and the risk of secondary exposure for the neonate.
Possible methods to be used, depending on stage of research project
1) Literature review and collection of lactational excretion data, data analysis of lactational excretion data. 2) Provide overview of regulatory guidelines, and investigate whether newly approved drugs adhere to these guidelines. 3) Milk composition analysis. Cowmilk will be used. Data analysis on the results. 4) physiologically based pharmacokinetic modelling of lactation.
Student interests
Veterinary medicines, translational science, comparative medicine, pharmacokinetics, biopharmaceutics, data mining, data analysis, regulatory.
Other
Work language is English.

Huvudområde

Farmaceutisk vetenskap

Ämne

Biofarmaci

Typ

Laborativ studie

Företag

Uppsala University

Ort/Plats

Uppsaala

Handledarens namn

Ilse Dubbelboer

Handledarens e-post

ilse.dubbelboer@farmbio.uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i biofarmaci 30 hp - 3FG008

Omfattning/hp

30hp

Hur många studenter kan antagas för detta projekt?

1

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