A comparative study of permeation enhancers, orally taken peptide therapeutics and their ability to permeate a model intestinal membrane investigated by the in-silico molecular dynamics simulation method’

Terrmin

HT23

Beskrivning

Aim:
1. Study how 100 mM sodium caprylate (C8) and 100 mM sodium caprate (C10) interact, respectively, with the peptide octreotide and how the respective formulation interacts with the model membrane.
2. Same as above but with the oral peptide semaglutide instead.
3. Starting randomly, and starting incorporated into one of the leaflets, respectively.
4. If time, to study octreotide, sodium caprylate and other components in a lipid base formulation as similar as possible to Mycapssa®

To study the effects and influence on a model POPC membrane.
- To study insertion, expulsion and potential flipflop events,
- water permeation,
- membrane structural properties such as area per lipid, membrane thickness, and lateral diffusion,
- order parameter
- aggregate formation
- insertion depth, if any

Huvudområde

Läkemedelsutveckling

Ämne

Läkemedelsformulering och Molekylär galenisk farmaci

Typ

Beräkningsstudie

Företag

Uppsala universitet

Ort/Plats

Uppsala

Handledarens namn

Per Larsson

Handledarens e-post

per.r.larsson@uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsmodellering

Kurs

Degree Project in Pharmaceutical Modelling within Pharmaceutics and Biopharmaceutics 45 c - 3FG001

Omfattning/hp

45hp

Hur många studenter kan antagas för detta projekt?

1

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