ProjektportalPharmacokinetic evaluation of ‘stryphnins’ from Stryphnus fortis, a marine sponge from the North Atlantic
Terrmin
HT23
Beskrivning
In our recent work, we have isolated an extremely stable class of disulfide-rich peptides, that we have named ‘stryphnins’ from Stryphnus fortis, a marine sponge from the North Atlantic. Stryphnins represent molecular scaffolds with potential utility as a drug delivery framework, due to their remarkable biological stability. The current project is aimed at studying the tissue distribution of stryphnins as well as their ability to transport across the blood-brain barrier. For this purpose, a bioanalytical method will be developed for the detection of stryphnins in rat plasma and brain homogenate and the pharmacokinetics of the peptides will be studied further in rats. The project will be jointly supervised by Dr. Sunithi Gunasekera, Pharmacognosy, Dept of Pharmaceutical Biosciences, Dr. Irena Loryan, translational PKPD group, Dept of Pharmacy and Dr. Helena Idborg, Department of Medicine, Karolinksa Instituet.
The work will be carried out in Uppsala, however in a research group, that offers an international environment. The working language, including supervision, will be English.
Does this project sounds like something for you? Apply here or contact the supervisor (see below) or Maria Kjellsson (maria.kjellsson@farmaci.uu.se) if you have additional questions. We look forward to your application!
Huvudområde
Farmaceutisk vetenskap
Ämne
Farmakokinetik
Typ
Laborativ studie
Företag
Uppsala University
Ort/Plats
Uppsala
Handledarens namn
Sunithi Gunasekera (70%) and Irena Loryan (30%)
Handledarens e-post
sunithi.gunasekera@farmbio.uu.se; irena.loryan@farmaci.uu.se
Institution
Institutionen för farmaci
Program
Masterprogram i biologiska läkemedel
Kurs
Degree Project in Biopharmaceuticals 45 hp - 3FB036
Omfattning/hp
45hp
Hur många studenter kan antagas för detta projekt?
1