ProjektportalLiterature review project on molecular imaging of the immune system
Terrmin
HT25
Beskrivning
Positron Emission Tomography (PET) is a state of the art biomedical imaging technique used all over the world for diagnosis of disease, by taking images of the body by a scanner, after administration of a radiolabeled contrast agent.
Inflammation is a major pathological feature of many devastating disorders, such as metabolic disease and cancer. Novel therapeutic strategies attempt to harness or modulate the activity of the bodys immune system in order to treat disease, examples include immune checkpoint therapy in cancer, or immune suppression in autoimmune disorders.
Current diagnostic techniques cannot accurately detect inflammation or immune system activity in tissue, and thus novel PET imaging technologies are under clinical development. These tools are expected to provide conceptually novel endpoints and diagnostic tools for selecting the right treatment for the right patient, and also to help follow up treatment efficacy.
This literature review project aims to summarise the preclinical and clinical development of novel PET tracers for detection of inflammation and immune cells.
Huvudområde
Läkemedelsutveckling
Ämne
Molekylär avbildning
Typ
Litteraturstudie
Företag
Uppsala Universitet
Ort/Plats
Uppsala
Handledarens namn
Olof Eriksson
Handledarens e-post
olof.eriksson@ilk.uu.se
Institution
Institutionen för Läkemedelskemi
Program
Masterprogram i läkemedelsutveckling
Kurs
Degree Project in Drug Discovery and Development 30 c - 3FK045
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
2