ProjektportalImmune response in tuberculosis infection
Terrmin
HT25
Beskrivning
Background: We are continuously exposed to allergens, toxins, and pathogens from the day we are born. When our body is infected, its first line of defense, the innate immune response, works to eliminate the infection or activate adaptive immunity. Early innate responses are critical because they can determine infection outcomes in humans. This is particularly important for infection with Mycobacterium tuberculosis, the bacterium that causes tuberculosis, since only 20–25% of individuals show signs of infection after exposure.1 Knowledge of the early immune response might inform new diagnostic markers, which could significantly impact tuberculosis treatment. However, our understanding of the innate response to M. tuberculosis is inconsistent, often varying according to whether studies are conducted in vivo or ex vivo, or whether cells originate from animals or humans.2,3 Exploring the time courses of immune components involved in activation and response can help us not only understand the immune response in both animals and humans but also assess the effects of novel anti-tubercular drugs.
Aim: The first aim of this study is to review findings on the immune components involved in activation and innate responses observed in in vivo mouse models infected with M. tuberculosis based on literature study. The second aim of this study is to quantify the in vivo innate immune response to M. tuberculosis infection through relevant plasma or lung immune components from experimental in vivo mouse models based on graphical analysis.
Method: A literature search will be conducted in databases such as the National Library of Medicine National Institutes of Health (PUBMED) or the Web of Science (WOS), using terms like “tuberculosis,” “Mycobacterium tuberculosis,” “innate immune response,” or “mouse models”. Data from experimental in vivo mouse models will be performed using R.
Contact: Thi Minh Nguyet Nguyen, nguyet.nguyen@uu.se or Ulrika Simonsson, ulrika.simonsson@uu.se
References:
1 Kontsevaya I, Cabibbe AM, Cirillo DM, et al. Update on the diagnosis of tuberculosis. Clin Microbiol Infect 2024; 30: 1115–22.
2 Sia JK, Rengarajan J. Immunology of mycobacterium tuberculosis infections. Gram-Positive Pathog 2019; 7: 1056–86.
3 Ravesloot-Chavez MM, Van Dis E, Stanley SA. The Innate Immune Response to Mycobacterium tuberculosis Infection. Annu Rev Immunol 2021; 39: 611–37.
Huvudområde
Farmaceutisk vetenskap
Ämne
Biofarmaci
Typ
Beräkningsstudie
Företag
Uppsala University
Ort/Plats
Uppsala
Handledarens namn
Thi Minh Nguyet Nguyen och Ulrika Simonsson
Handledarens e-post
nguyet.nguyen@uu.se
Institution
Institutionen för farmaceutisk biovetenskap
Program
Apotekarprogrammet
Kurs
Fördjupningsprojekt i biofarmaci 30 hp - 3FG008
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1