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Novel Combinations of Beta-lactamase Inhibitors and Antibiotics: systematic literature review and meta-analysis

Terrmin

HT25

Beskrivning

Background
The rise of antibiotic resistance poses a significant threat to global health, necessitating innovative approaches to combat resistant bacterial infections. Beta-lactamase inhibitors have emerged as a promising solution, enhancing the efficacy of existing antibiotics against resistant strains. This project aims to conduct a systematic literature review and meta-analysis to evaluate the efficiency of novel combinations of beta-lactamase inhibitors with traditional antibiotics in specific patient groups and infections, to be defined by the student. By analyzing current evidence, we aim to identify the most effective combinations for clinical use. The thesis may be written in English or in Swedish.

Methodology
1. Systematic Literature Review:
- Develop a comprehensive search strategy to identify relevant studies from databases such as PubMed, Cochrane Library, and Embase.
- Include studies that evaluate the efficacy of novel beta-lactamase inhibitors combined with traditional antibiotics in treating specific bacterial infections for specific patient groups.
2. Data Extraction and Quality Assessment:
- Extract relevant data, including patient demographics, infection types, treatment regimens, and outcomes.
- Assess the quality of the studies using standardized tools such as the Cochrane Risk of Bias tool or the Newcastle-Ottawa Scale.
3. Meta-Analysis:
- Perform a meta-analysis to quantitatively analyze the data and compare the efficacy and safety profiles of the antibiotic combinations.
- Conduct subgroup analyses to explore variations in treatment efficacy based on factors such as infection type and patient characteristics.

Expected Results
The project is expected to provide a comprehensive report of existing evidence on the efficacy of novel beta-lactamase inhibitors in antibiotic combinations. We anticipate identifying combinations that offer superior efficacy and safety profiles, as well as highlighting the impact of antibiotic resistance on treatment outcomes. The findings will contribute to optimizing treatment strategies for resistant bacterial infections and support evidence-based clinical decision-making.
This project will also provide students with valuable experience in conducting systematic reviews and meta-analyses, developing skills in data extraction, quality assessment, and statistical analysis essential for clinical research in pharmaceutical microbiology.

Huvudområde

Farmaceutisk vetenskap

Ämne

Mikrobiologi, infektionsbiologi

Typ

Litteraturstudie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Karin Hjort

Handledarens e-post

karin.hjort@imbim.uu.se

Institution

Institutionen för medicinsk biokemi och mikrobiologi

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i farmaceutisk mikrobiologi 30 hp - 3FM212

Omfattning/hp

30hp