Evaluation of bacteria counts from time-lapse microscopy using an existing colony-forming unit (CFU) model

Terrmin

HT25

Beskrivning

Time-lapse imaging has the potential to increase the time-resolution of bacterial counts, but the differences between traditional CFU counts and time-lapse imaging counts are still unclear. In this project, bacterial counts obtained from time-lapse images using an existing image analysis pipeline will be used to re-estimate parameters from existing CFU-based PKPD model. Changes in the model required due for the time-lapse imaging can be evaluated and discussed. The dataset consists of E. coli exposed to ertapenem at a range of concentrations for up to 24 hours.

The work will be carried out in Uppsala in an international environment. The working language, including supervision, will be English.

Does this project sounds like something for you? Apply here or contact the supervisor (see below) or Maria Kjellsson (maria.kjellsson@uu.se) if you have additional questions. We look forward to your application!

Huvudområde

Farmaceutisk vetenskap

Ämne

Farmakometri

Typ

Beräkningsstudie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Eva Wehrhahn

Handledarens e-post

eva.wehrhahn@uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsmodellering

Kurs

Degree Project in Pharmaceutical Modeling within Pharmacometrics 45 c - 3FB029

Omfattning/hp

45hp

Hur många studenter kan antagas för detta projekt?

1

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