Projektportal

Startsida Om denna webbplats

Logga in

Physiologically based pharmacokinetic modelling of vulnerable or neglected populations

Terrmin

HT25

Beskrivning

Aim
To develop physiologically based pharmacokinetic (PBPK) models to assess the biopharmaceutic and/or pharmacokinetic behaviour of medicines in the fields of lactation or veterinary pharmacology.
Background
PBPK models are mechanistic models describing the physiology of a human or an animal. These mechanistic models are compartment-based, and each compartment is described with physiologically relevant parameters. Physiologically based blood flows from and to these organs determine the mass transfer of the drug to and from the compartments. PBPK modelling can be used to study the effect of formulation, food or other biopharmaceutical aspects on the absorption of the drug. The PK of drugs can be assessed in vulnerable or neglected populations.
One vulnerable population are breastfeeding mothers and their babies. The majority of medicines have no or weak lactation-specific information. This causes a portion of mothers to stop breastfeeding. And when not, the drug consumption during breastfeeding poses a potential risk for the baby. With PBPK modelling, an initial assessment of lactational drug transfer can be made.
Our hourse pets can be seen as an invisible population, especially with regards to the use of antibiotics. Optimal drug treatment, giving a high enough dose to kill the bacteria, whilst simultaneously keeping the use of antibiotics to a minimum, is essential. Not only for humans, but also for pets. PBPK modelling can assist with assessment of the right dose and the biopharmaceutical effects of dosage forms on the PK.
Possible methods to be used
Build PBPK model(s) with PK-Sim & MoBi (Open Systems Pharmacology Suite). PBPK modelling will be used to investigate one of two research interests: lactational excretion of drugs or veterinary pharmacology. The direction of the project will be decided depending on stage of research project, student interest and in discussion with the supervisor.
Student interests
Veterinary medicines, translational science, pharmacokinetics, biopharmaceutics, lactational drug excretion, comparative medicine, data mining, data analysis, regulatory, mechanistic pharmacokinetic modelling. Knowledge of or the interest in R or other programming languages, biopharmaceutics and pharmacokinetics is essential to this project.
Other
Work and writing language is English. Student is expected to work fulltime (40h) at university
throughout the whole project, even when project is not experimental.

Huvudområde

Farmaceutisk vetenskap

Ämne

Biofarmaci

Typ

Beräkningsstudie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Ilse Dubellboer

Handledarens e-post

ilse.dubellboer@uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i biofarmaci 30 hp - 3FG008

Omfattning/hp

30hp