ProjektportalImpact of constraint factor on prediction of tabletability
Terrmin
HT25
Beskrivning
Background:
One important tablet quality attribute is the tablet tensile strength. This is often product specific and depends on the composition of the powder and the pressure applied during manufacturing. The tablet tensile strength must be high enough to ensure the coherency of the tablet during e.g. further processing such as coating and transportation but also low enough to enable tablet disintegration after administration. The tablet tensile strength is a function of the inter-particulate contact area that is controlled by the particle hardness. The relationship between particle hardness and particle plastic stiffness is denoted constraint factor. A general value of this factor is typically used but indications that the value can be material specific are evident. This value is of importance as it has shown to be a vital parameter in predictions of tabletability.
Aim:
The aim of the project is to first study how the mechanical properties of powder materials affect the value of the constraint factor. Secondly the aim is to study this impact of prediction of tabletability.
Outcome:
The expected outcome is to gain improved knowledge of how mechanical properties influences the constraint factor that ultimately can be used as a tool for characterizing tableting performance of a powder during early formulation development.
Huvudområde
Farmaceutisk vetenskap
Ämne
Galenisk farmaci
Typ
Laborativ studie
Företag
Uppsala Universitet
Ort/Plats
Uppsala
Handledarens namn
Ann-Sofie Persson (UU) och Josefina Nordström (UU)
Handledarens e-post
ann-sofie.persson@uu.se
Institution
Institutionen för farmaceutisk biovetenskap
Program
Apotekarprogrammet
Kurs
Fördjupningsprojekt i galenisk farmaci med inriktning mot farmaceutisk teknologi 30 hp - 3FB033
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1