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Population Pharmacokinetic (PopPK) Modeling of First-Line Tuberculosis (TB) Drugs in Tuberculous Meningitis Treatment

Terrmin

HT25

Beskrivning

Tuberculous meningitis (TBM) is the most severe form of tuberculosis, often leading to high mortality and morbidity due to suboptimal drug penetration into the central nervous system (CNS). Understanding the pharmacokinetics (PK) of first-line TB drugs—rifampicin, isoniazid, ethambutol, and pyrazinamide—within plasma and cerebrospinal fluid (CSF) is crucial for optimizing treatment regimens. The project will entail building a population PK (popPK) model for one of the first-line TB treatment drug to assess individual drug exposure in the plasma and CSF and identifying covariates, and potsential predictors for the distribution to CSF. If applicable, a published model will be used to further develop the model using NONMEM. The analysis will utilize plasma and CSF concentration data from a phase 3 clinical trial (HARVEST), which compared high-dose rifampicin (35 mg/kg) to the standard dose (10 mg/kg) in TBM treatment.

The work will be carried out in Uppsala, in a research group, that offers an international environment. The working language, including supervision, will be English.

Does this project sounds like something for you? Apply here or contact the supervisor (see below) or Maria Kjellsson (maria.kjellsson@uu.se) if you have additional questions. We look forward to your application!

Huvudområde

Farmaceutisk vetenskap

Ämne

Farmakometri

Typ

Beräkningsstudie

Företag

Uppsala University

Ort/Plats

Uppsala

Handledarens namn

Youjung Cho, Elin Svensson

Handledarens e-post

youjung.cho@uu.se, elin.svensson@uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsmodellering

Kurs

Degree Project in Pharmaceutical Modeling within Pharmacometrics 45 c - 3FB029

Omfattning/hp

45hp