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Ceramic drug carrier for tamper resistant oral drug delivery

Terrmin

HT24

Beskrivning

Aim
The objective of the project is to develop a formulation and manufacturing method for mechanically strong drug loaded ceramic carriers. The intended use of the carriers is extended release of opioids for either opioid use disorder or moderate to severe pain. The project aims to document the tamper-resistant properties and drug release in a preclinical setting.

Background
Each prescription for opioids carries the inherent risk of addiction. The abuse and misuse of prescription opioids frequently serve as the starting point for a lifelong struggle with addiction, emphasizing the urgent need for multiple measures to prevent addiction and overdoses. This issue is particularly pressing in the United States, where opioid abuse and overdoses pose significant social and economic challenges. Consequently, the U.S. Food and Drug Administration (FDA) is actively advocating for the development of safer products utilizing abuse-deterrent formulations, which restrict drug abusers from quickly accessing high quantities of opioids. In response to this pressing need, Emplicure has pioneered a technology that combines extended-release properties with abuse-deterrent characteristics. By employing a ceramic material with exceptional mechanical strength, Emplicure's abuse-deterrent formulation offers a novel approach.

My task
• To test the formulation parameters including ceramic composition, API concentration, mixing time, and setting characteristics. The material formulation will be analyzed using X-ray diffraction, porosimetry and the granule size distribution.
• Determine drug release characteristics through release testing using HPLC.
• Bench testing of the tamper resistance of the formulation.

Huvudområde

Läkemedelsutveckling

Ämne

Läkemedelsformulering och Molekylär galenisk farmaci

Typ

Laborativ studie

Företag

Emplicure

Ort/Plats

Uppsala

Handledarens namn

Anna Franzén, Jesper Lööf

Handledarens e-post

per.r.larsson@uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsutveckling

Kurs

Degree project in Drug Discovery and Development 45 c -3FK044

Omfattning/hp

45hp