Prediction of tabletability of binary powder mixtures using a hybrid approach

Terrmin

HT24

Beskrivning

Background: One important tablet quality attribute is the tablet tensile strength. This is often product specific and depends on the composition of the powder blend and the pressure applied during manufacturing. The relationship between tablet tensile strength and compaction pressure is commonly denoted a tabletability relationship. By using a three-stage model, tabletability of single component powders can be predicted with a hybrid approach based on some compression parameters generated from one single compression experiment. As pharmaceutical products generally are composed of two or more components it is thus of interest to study the applicability of the approach for binary mixtures.

Aim: The general aim is to study the possibility to predict the tablet tensile strength for binary powder mixtures using a three-stage compaction model describing the strength-pressure relationship. Specific aims will be discussed together with the project student.

Method: The project is experimental and laboratory work at BMC will be conducted by the student.

Expected outcome: It is expected that the study will bring knowledge on the applicability of the hybrid prediction approach on powder mixtures.

Huvudområde

Farmaceutisk vetenskap

Ämne

Galenisk farmaci

Typ

Laborativ studie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Ann-Sofie Persson, Josefina Nordström och Göran Alderborn

Handledarens e-post

ann-sofie.persson@uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i galenisk farmaci med inriktning mot farmaceutisk teknologi 30 hp - 3FB033

Omfattning/hp

30hp

Hur många studenter kan antagas för detta projekt?

1

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