ProjektportalInhalation powders prepared by spray drying
Terrmin
HT24
Beskrivning
Background
Drug delivery to the lungs is commonly used to treat diseases such as asthma and chronic obstructive pulmonary disease. The lungs have a large surface area available for absorption, a high vascularization, and a thin blood-alveolar barrier, which makes the pulmonary delivery route an interesting alternative for a range of drugs, including new modalities (e.g. insulin, vaccines and growth hormones). Drug delivery to the lung is generally accomplished with an inhaler. Out of these, the dry powder inhalers (DPIs) have become increasingly popular during the last decades, thanks to advantages related to stability of the drug substance, versatility and ease of operation. Traditionally, inhalation powders have with some exceptions been designed in the form of carrier-based formulations (adhesive mixtures). However, there is today an increased interest in using spray drying to prepare inhalation powders for different types of drugs and to use these as so-called carrier-free formulations. With adequate processing parameters, it is possible to retain the biological activity of heat-sensitive drugs such as peptides, oligonucleotides and other biologics. Moreover, higher doses of active pharmaceutical ingredients (APIs) can potentially be delivered to the lung if carrier-free formulations are used.
Your task
The overall aim of the project is to provide an improved understanding of how the composition and manufacturing conditions affect the performance of inhalation powders. Your task will therefore be, first, to prepare powders with different compositions and possibly different processing parameters and, second, to characterize the obtained powders, e.g. in terms of aerosolization performance.
Huvudområde
Farmaceutisk vetenskap
Ämne
Galenisk farmaci
Typ
Laborativ studie
Företag
Uppsala universtitet
Ort/Plats
Uppsala
Handledarens namn
Göran Frenning
Handledarens e-post
goran.frenning@uu.se
Institution
Institutionen för farmaceutisk biovetenskap
Program
Apotekarprogrammet
Kurs
Fördjupningsprojekt i galenisk farmaci med inriktning mot farmaceutisk teknologi 30 hp - 3FB033
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1