ProjektportalThe effect of dry binders on the tableting performance of dry granulated particles
Terrmin
HT24
Beskrivning
The most common dosage form is the tablet which typically is manufactured by uniaxial compaction of a powder pre-metered into a die by gravitational flow. A common way to convey flowability to a fine powder that should be compacted into tablets is to transform the fine powder into granules by a dry granulation technology, i.e. to form compacts (slugs) by the application of pressure on the fine powders which subsequently are broken down into granules by milling. The ability of the dry granulated particles to cohere into a tablet depends on the composition of the powder blend, the porosity of the granules and the pressure applied during tablet formation. In this project, powder mixtures including a low proportion of a highly deformable material (a dry binder) is prepared and dry granulated by a slugging-milling process. The aim of the project is study the effect of the dry binder on the tableting performance of the dry granulated particles. The dry binders may have an impact on both the plastic deformation of the granules and their specific ability to bond to each other. The ambition of the project is to resolve the relative effect of the dry binder on the plasticity and specific bondability of the dry granulated particles. Analytical powder compression will be used as a means to characterize the plasticity of the dry binder particles and of the granules.
Huvudområde
Farmaceutisk vetenskap
Ämne
Galenisk farmaci
Typ
Laborativ studie
Företag
Uppsala Universitet
Ort/Plats
Uppsala
Handledarens namn
Göran Alderborn, Ann-Sofie Persson, Josefina Nordström
Handledarens e-post
goran.alderborn@uu.se; ann-sofie.persson@uu.se; josefina.nordstrom@uu.se
Institution
Institutionen för farmaceutisk biovetenskap
Program
Apotekarprogrammet
Kurs
Fördjupningsprojekt i galenisk farmaci med inriktning mot farmaceutisk teknologi 30 hp - 3FB033
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1