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3D-printed lipid mesophases for oral antibiotic delivery

Terrmin

HT24

Beskrivning

Aim
To develop and optimize 3D-printed lipid mesophases (LMPs) loaded with a model antibiotic for oral drug delivery.
Background
Lipid-based formulations are promising for enhancing the oral bioavailability of lipophilic drugs by creating colloidal particles in the gastrointestinal tract, thereby improving drug solubility. Despite the success of various delivery systems in commercial and clinical settings, incorporating lipids into solid oral dosage forms presents challenges due to their limited versatility compared to traditional excipients. The utilization of 3D-printing in pharmaceutics and personalized medicine has gained attention, allowing for customizable dosing, production of polypills, and adjustable drug release profiles. Lipid mesophases (LMPs) have promising characteristics as ink for 3D printing tablets. Lipid mesophases (LMPs), a subset of materials within the liquid crystalline phase formed spontaneously when lipids are mixed with water, exhibit promising attributes as ink for 3D-printing tablets. LMPs provide customizable nanostructures and mechanical properties essential for effective material engineering in 3D printing applications.
Methods
This project will build upon our recent work on liquid crystalline phases, allowing us to tailor lipid mesophases by adjusting water content, temperature, or incorporating additives. This customization enables us to achieve various geometries such as lamellar (L), cubic (QII), inverse hexagonal (HII), or micellar, each influencing drug release rates, viscosity, and self-emulsification mechanisms. We will explore correlations between nanostructure and properties, develop printable LMPs, and characterize 3D-printed tablets using the following methods:
? Develop LMP ink using a phase diagram based on water, phytantriol and ?-tocopherol and small-angle X-ray scattering (SAXS) for determination of lipid mesophase. Other lipid compositions may be explored based on our previous experience. Load LMP ink with model antibiotic.
? Assess rheological properties of LMP ink using a state-of-the-art rheometer.
? 3D-printing of tablets and optimization of printing parameters (infill density, speed, pressure etc.).
? Characterize 3D-printed tablets for drug loading, mass uniformity and disintegration time.
My task
To develop one LMP ink loaded with a model antibiotic (vancomycin) and tune its properties towards 3D printing of a final dosage form. To characterize 3D printed tablets.
Expected results:
This project aims to develop optimized 3D-printed lipid mesophases (LMPs) loaded with a model antibiotic. Through customization of LMP ink formulations and characterization of rheological properties, we anticipate the successful fabrication of uniform 3D-printed tablets with efficient drug loading and disintegration. The developed LMP ink, loaded with vancomycin, will demonstrate its potential for oral antibiotic delivery.

Huvudområde

Läkemedelsutveckling

Ämne

Läkemedelsformulering och Molekylär galenisk farmaci

Typ

Laborativ studie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Madlen Hubert

Handledarens e-post

madlen.hubert@farmaci.uu.se

Institution

Institutionen för farmaci

Program

Masterprogram i läkemedelsutveckling

Kurs

Degree project in Drug Discovery and Development 45 c -3FK044

Omfattning/hp

45hp