Does the Bri2 BRICHOS function as a chaperone in amyloidogenesis?

Terrmin

HT24

Beskrivning

Does the Bri2 BRICHOS function as a chaperone in amyloidogenesis?

Misfolded proteins can escape degradation and accumulate in various tissues. More than 30 proteins have been identified as amyloid-forming in humans, and each protein is linked to a specific disease. A well-known amyloid disease is Alzheimer's disease, where the protein Abeta accumulates as amyloid in the patient's brain. Bri2 is a multi-domain protein containing a BRICHOS domain that has been ascribed a chaperone-like function preventing aggregation of amyloid-prone proteins.
The aim of the project is to use drosophila melanogaster and investigate if the BRICHOS domain can prevent aggregation and toxicity of the amyloid protein transthyretin.

Huvudområde

Farmaceutisk vetenskap

Ämne

Fysiologi

Typ

Laborativ studie

Företag

Uppsala Universitet

Ort/Plats

BMC

Handledarens namn

Gunilla Westermark

Handledarens e-post

gunilla.westermark@mcb.uu.se

Institution

Institutionen för medicinsk cellbiologi

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i fysiologi 30 hp - 3MC333

Omfattning/hp

30hp

Hur många studenter kan antagas för detta projekt?

1

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