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Is the approved dose appropriate for treatment of bovine respiratory disease?

Terrmin

HT24

Beskrivning

Aim
To evaluate whether the dosing ranges given for an approved antibiotic are effective for treating bovine respiratory disease.
Background
All approved medicines have a given dose range which is approved for a certain species, age category and sometimes even disease. In practice, the administered doses can deviate from the approved doses. It is time to evaluate how well the approved doses would treat bovine respiratory disease.
Methods
Collating data from relevant SPC to obtain the dosing ranges approved in the EU. This includes translating SPCs from different EU countries, and keeping track of several hundreds of documents. Simulating the plasma-concentration time curves with a population-PK cow model to evaluate whether the treatment goal is reached.
Student interests and traits
Veterinary medicines, efficacy, antibiotic treatment. Interest in pharmaceutical modelling. Detail focussed, careful and orderly. Good excel skills are a must.
Note
The student will work at BMC. The investigative drug is to be determined by the supervisor. The working and writing language will be English. This project is part of an ongoing international collaboration with the One Health Pharmacology group at Utrecht University in the Netherlands.
Contact / Supervisor
Ilse Dubbelboer, ilse.dubbelboer@uu.se
Researcher, Pharmaceutical Biosciences, Uppsala University

Huvudområde

Farmaceutisk vetenskap

Ämne

Biofarmaci

Typ

Beräkningsstudie

Företag

Uppsala Universitet

Ort/Plats

Uppsala

Handledarens namn

Ilse Dubberboer

Handledarens e-post

ilse.dubberboer@uu.se

Institution

Institutionen för farmaceutisk biovetenskap

Program

Apotekarprogrammet

Kurs

Fördjupningsprojekt i biofarmaci 30 hp - 3FG008

Omfattning/hp

30hp