ProjektportalValidation of pharmacometric multistate model for patients with tuberculosis using TB-PACTS database
Terrmin
HT24
Beskrivning
Tuberculosis remains a significant global health challenge with approximately 10 million new cases reported annually. Early and reliable biomarkers are urgently needed for studying long-term outcomes of tuberculosis. We have previously developed a pharmacometric multistate model for predicting tuberculosis treatment outcomes. This framework enables mechanistically sound investigation of novel promising biomarkers in tuberculosis research. However, the robustness and applicability of this multistate model framework should be evaluated by external validation.
This project aims to assess the generalizability of a previously developed multistate model for tuberculosis by utilizing the Tuberculosis Platform for Aggregation of Clinical TB Studies (TB-PACTS) database. This will enhance the robustness and reliability of its prospective application of future biomarker evaluation, clinical trial design and analysis.
ngaging in this project offers the opportunity to collaborate within a cutting-edge and highly international pharmacometric research group. One can deepen their understanding of tuberculosis treatment and related biomarkers while acquiring practical skills in clinical trial data management and programming in both R and NONMEM. The work will be carried out in Uppsala and the working language, including supervision, will be English.
Does this project sounds like something for you? Apply here or contact the supervisor (see below) or Maria Kjellsson (maria.kjellsson@farmaci.uu.se) if you have additional questions. We look forward to your application!
Huvudområde
Farmaceutisk vetenskap
Ämne
Farmakometri
Typ
Beräkningsstudie
Företag
Uppsala Universitet
Ort/Plats
Uppsala
Handledarens namn
Yu-Jou Lin and Elin Svensson
Handledarens e-post
yu-jou.lin@farmaci.uu.se;elin.svensson@farmaci.uu.se
Institution
Institutionen för farmaci
Program
Masterprogram i läkemedelsmodellering
Kurs
Degree Project in Pharmaceutical Modeling within Pharmacometrics 45 c - 3FB029
Omfattning/hp
45hp
Hur många studenter kan antagas för detta projekt?
1