Subcutaneous administration are a widely used practice in clinical medicine today. Particularly the fast growing numbers of biomolecular drugs e.g. antibodies, human growth hormone and insulin with limited oral bioavailability are administrated through the subcutaneous route. There are several formulations for delivering these drugs, the most common being solutions, suspensions and emulsions. One less explored formulation method that is promising both for immediate release and modified release formulations are coacervates. Coacervates can be defines as a highly concentrated liquid phase, and are able to contain higher concentrations than regular solutions. Coacervates are often a mixture of a charged polymer called a polyelectrolyte and a drug molecule.
In this project you will work with developing new coacervate formulations by mixing different non-toxic polyelectrolytes e.g. Hyaluronic acid, Carboxymethyl cellulose with relevant drugs. Then modify the physicochemical parameters in these mixtures such as pH, ionic strength and proportions of components to create stable coacervates suitable for subcutaneous injection. Finally you will test the release of drugs from these coacervates into release mediums mimicking the subcutaneous tissue by utilizing UV-spectroscopy.
This master project is performed within The Swedish Drug Delivery Center (SweDeliver) which is a collaboration between Uppsala University and a large number of pharmaceutical companies, such as AstraZeneca, Ferring and Orexo.
Supervisors: Marcus Wanselius and Per Hansson
Per Hansson, Marcus Wanselius