ProjektportalLäkemedel i mjölk/Drugs in milk
Terrmin
VT22
Beskrivning
Läkemedel i mjölk/Drugs in milk
Aim
To investigate which drugs are excreted to milk and elucidate the mechanisms behind the elimination.
Background
Milk is a source of energy and macronutrients, but it is also a source of neonatal exposure to xenobiotics, such as phytochemicals, pharmaceutical compounds or drugs and toxins. These small molecules are passed from the blood across the mammary epithelial blood-milk barrier to the milk of lactating mammals, such as cows, sheep, goats and humans. Milk can therefore be regarded as a route of elimination of these compounds in the lactating adult, and a source of secondary exposure to the offspring and other consumers of dairy products. In food-producing animals receiving pharmaceuticals, residue studies are done to determine the withdrawal time. Withdrawal time is the time that must elapse between the last administration of a veterinary medicine and production of milk, to ensure that the food does not contain levels of the medicine that exceed the maximum residue limit. After the withdrawal time, the milk can be added to the food chain again.
Drugs are eliminated to the milk by diffusion and active transport. The breast cancer resistance protein plays a large role in eliminating drugs to milk. But the composition of milk might also facilitate the diffusion of compounds to milk.
Methods
15hp: Literature overview of one of the following: drugs excreted to milk, binding of drugs to milk, milk composition. The overview can be on milk of any type of lactating mammal.
30 & 45hp: Performing experimental work on for example the composition of milk and properties of drugs, binding of drugs to milk components, solubility of drugs in milk, dissolution of drugs in milk. Experiments will be performed on cow milk. Analysis with HPLC will be included. Literature overview is likely included. It is possible that method development is part of the project.
Student interests
15, 30 & 45 hp: Veterinary medicines, translational science, food production, pharmacokinetics.
30 & 45hp: Hands-on experiments in the lab, method development
Contact / Supervisor
Ilse Dubbelboer, ilse.dubbelboer@farmbio.uu.se
Researcher @SweDeliver, Pharmaceutical Biosciences, Uppsala University &
PostDoc @One Health Pharmacology, Institute for Risk Assessment Sciences, Department Population Health Sciences, Veterinary Medicine, Utrecht University
Huvudområde
Farmaceutisk vetenskap
Ämne
Biofarmaci
Typ
Laborativ studie
Företag
Uppsala University
Ort/Plats
Uppsala
Handledarens namn
Ilse Dubbelboer
Handledarens e-post
ilse.dubbelboer@farmbio.uu.se
Institution
Program
Kurs
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1