ProjektportalThe effect of the menstrual cycle on glucose metabolism after sleep deprivation
Terrmin
VT22
Beskrivning
Our current 24-h economy results in frequent occurrence of shift work. In Europe, 19% of the working population works during the night at least once a month. Night shift work disrupts circadian rhythms and has been associated with an increased risk for obesity, metabolic syndrome, and glucose dysregulation. The circadian system also regulates insulin signaling and insulin action in tissues such as the liver, adipose, and skeletal muscle which are critical for metabolic control in type 2 diabetes. Consequently, disruption of circadian rhythms and/or tissue-specific clock gene deletion impair insulin action and induce glucose intolerance. Additionally, estrogen is involved in glucose homeostasis and energy metabolism. In particular, estrogen deficiency has been associated with increased insulin resistance and type 2 diabetes. It is not clear the effect of the menstrual cycle on night shift work and on health. Previous studies investigating the effects of sleep deprivation include young healthy men and women on hormonal contraceptives. In this study, we, therefore, want to focus on hormone-free women with a regular menstrual cycle to examine the possible sex-dependent response to sleep deprivation and stress. We hypothesize a greater impairment on morning glucose tolerance after sleep deprivation in the early follicular phase characterized by low levels of estrogen compared to the late follicular phase. Aim of the study is to assess whether the menstrual cycle phase plays a role in glucose metabolism after one night of total sleep deprivation. Approach: The project will recruit 48 women between the ages of 18-30, with a BMI ranging from 18.5-24.9 and a regular menstrual cycle. The study will include in total 5 experimental nights: one adaptation night, two nights of total sleep deprivation, and two nights with 8 hours of sleep opportunity. Each phase of the cycle (early vs. late follicular phase) will begin with one night of sleep followed by a night of total sleep deprivation. During the experiments, sleep will be tracked through different equipment such as dreem headband and Withings sleep analyzer. The participants will perform a number of cognitive and metabolic tests during the sessions including eye-tracking, heart rate monitoring, metabolic assessment using COSMED K5, OGTT test, saliva sampling, and blood sampling. The glucose metabolism will be measured by performing an oral glucose tolerance test (OGTT).
Huvudområde
Farmaceutisk vetenskap
Ämne
Farmakologi
Typ
Laborativ studie
Företag
Uppsala Universitet
Ort/Plats
BMC
Handledarens namn
Christian Benedict
Handledarens e-post
christian.benedict@neuro.uu.se
Institution
Program
Kurs
Omfattning/hp
30hp
Hur många studenter kan antagas för detta projekt?
1